Contagious Bovine Pleuropneumonia (CBPP) Nucleic Acid Test Kit (Lyophilized)

Symptoms

• Respiratory Distress: Cattle infected with the causative agent of CBPP, Mycoplasma mycoides subsp. mycoides, often display severe respiratory symptoms. This includes rapid and labored breathing, with an increased respiratory rate that can be significantly higher than normal (up to 60 - 80 breaths per minute in severe cases). Cattle may show open - mouth breathing, gasping, and a characteristic "thumping" sound as they struggle to inhale and exhale.

• Coughing: A persistent cough is a common symptom. It may start as a dry cough but can become more productive over time, with the expulsion of mucus. The cough can be triggered by movement, stress, or changes in environmental conditions.

• Fever: Infected animals typically develop a fever, with body temperatures rising to 40°C - 42°C (104°F - 107.6°F). The fever is often accompanied by general malaise, depression, and a loss of appetite.

• Weight Loss: Due to the respiratory distress and reduced feed intake, cattle with CBPP gradually lose weight. In severe cases, the weight loss can be substantial, leading to emaciation and a significant decline in the animal's overall condition.

• Pleuritic Pain: The inflammation of the pleura (the lining of the lungs and chest cavity) causes pain. Cattle may show signs of discomfort, such as reluctance to move, standing with an arched back, and flinching when the chest area is palpated.

Clinical Applications

• Early Detection and Isolation: The CBPP nucleic acid detection reagent allows for the rapid and accurate identification of the pathogen in the early stages of infection. When cattle show even mild respiratory symptoms or are part of a high - risk group (such as newly introduced animals), this reagent can quickly determine if CBPP is present. Early detection enables immediate isolation of infected animals to prevent the spread of the disease within the herd.

• Herd Screening and Surveillance: Regular screening of cattle herds using the CBPP nucleic acid detection reagent is crucial for monitoring the health status of the herd. In endemic areas, where the disease is more prevalent, routine testing can help identify subclinical carriers that may be spreading the infection unnoticed. This information is essential for implementing effective control measures, such as vaccination, biosecurity improvements, and culling of infected animals.

• Differential Diagnosis: Respiratory diseases in cattle can have multiple causes, and CBPP can be confused with other conditions like bovine respiratory syncytial virus (BRSV) infection, bovine parainfluenza virus 3 (BPIV - 3) infection, or pneumonia caused by bacteria. The nucleic acid detection reagent helps veterinarians accurately distinguish CBPP from other respiratory pathogens, ensuring appropriate treatment and management strategies are employed.

• Import - Export and Quarantine: In international trade of cattle, the CBPP nucleic acid detection reagent is an important tool for quarantine purposes. It helps ensure that imported cattle are free from the disease, preventing the introduction of CBPP into disease - free regions. Similarly, for exported cattle, it provides assurance that they meet the health requirements of the destination country, facilitating smooth trade and maintaining the biosecurity of both the exporting and importing regions.

• Vaccine Efficacy Evaluation: For cattle that have been vaccinated against CBPP, the nucleic acid detection reagent can be used to assess the effectiveness of the vaccine. By testing vaccinated animals, it is possible to determine if the vaccine has induced sufficient immunity to prevent infection or at least reduce the severity of the disease. If the vaccine is not performing as expected, adjustments to the vaccination protocol can be made.